Introduction
Beef Lombardi Casserole is a hearty, layered dish that combines ground beef, egg noodles, and a rich blend of cheeses with Italian-inspired flavors. This beloved Southern casserole is perfect for family dinners and potlucks, offering layers of comfort in every bite.
Ingredients
For the Meat Sauce:
- 2 pounds lean ground beef
- 1 large onion, finely chopped
- 3 cloves garlic, minced
- 2 (14.5 oz) cans diced tomatoes
- 1 (8 oz) can tomato sauce
- 1 tablespoon Italian seasoning
- 1 teaspoon sugar
- Salt and black pepper to taste
For the Casserole:
- 12 oz egg noodles
- 16 oz sour cream
- 8 oz cream cheese, softened
- 1 cup green onions, chopped
- 2 cups shredded mozzarella cheese
- 1 cup shredded parmesan cheese
- 1/2 cup white wine (or chicken broth)
- 2 tablespoons butter
Instructions
Prepare the Meat Sauce
- Brown ground beef in a large skillet over medium heat
- Add onions and garlic, cook until onions are translucent
- Drain excess fat
- Add diced tomatoes, tomato sauce, Italian seasoning, sugar, salt, and pepper
- Simmer for 20-25 minutes until slightly thickened
- Stir in white wine and simmer for additional 5 minutes
Prepare the Noodles
- Cook egg noodles according to package directions
- Drain and toss with butter
- Set aside
Prepare the Cream Layer
- In a bowl, mix softened cream cheese and sour cream until smooth
- Fold in chopped green onions
- Season with salt and pepper
Assembly
- Preheat oven to 350°F (175°C)
- Grease a 9×13 inch baking dish
- Layer ingredients as follows:
- Half of the buttered noodles
- Half of the meat sauce
- Half of the cream cheese mixture
- Half of the mozzarella and parmesan
- Repeat layers

Baking
- Cover with foil and bake for 35 minutes
- Remove foil and bake additional 10-15 minutes until cheese is golden brown
- Let rest for 10-15 minutes before serving
Tips for Success
- Use lean ground beef to prevent excess grease
- Don’t overcook the noodles; they’ll continue cooking in the oven
- Bring cream cheese to room temperature for easier mixing
- Use freshly grated cheese for better melting
- Let casserole rest before serving to set properly
Make-Ahead Instructions
- Assemble casserole up to 24 hours in advance
- Cover tightly and refrigerate
- Add 10-15 minutes to covered baking time if cooking from cold
Storage and Reheating
- Refrigerate leftovers for up to 4 days
- Can be frozen for up to 3 months
- Thaw overnight in refrigerator before reheating
- Reheat individual portions in microwave
- Reheat larger portions covered in oven at 325°F
Variations
- Add mushrooms to the meat sauce
- Include a layer of sautéed spinach
- Use different cheese combinations
- Add red pepper flakes for heat
- Substitute ground turkey for beef
- Use ziti or penne instead of egg noodles
Serving Suggestions
- Serve with garlic bread
- Pair with a simple green salad
- Add steamed vegetables as a side
- Garnish with fresh basil or parsley
- Offer extra parmesan cheese at the table
This Beef Lombardi Casserole is the epitome of comfort food, combining the best elements of Italian and Southern American cuisine. The layers of flavors and textures create a satisfying meal that’s sure to become a family favorite. Whether served for a weeknight dinner or special occasion, this casserole delivers warmth and satisfaction in every serving.